{"id":84,"date":"2020-01-22T20:45:10","date_gmt":"2020-01-22T20:45:10","guid":{"rendered":"https:\/\/uwdpt-research.rehab.washington.edu\/brown-cardiopulmonary\/?page_id=84"},"modified":"2025-10-18T17:27:32","modified_gmt":"2025-10-18T17:27:32","slug":"projects","status":"publish","type":"page","link":"https:\/\/uwdpt-research.rehab.washington.edu\/brown-cardiopulmonary\/projects\/","title":{"rendered":"Projects"},"content":{"rendered":"

Ongoing projects<\/h2>\n

“Remotely-monitored Exercise to Enhance Functional Outcomes in Patients with Pulmonary Arterial Hypertension (PAH) Initiating Sotatercept Therapy: A Single-site Feasibility Study<\/strong>\u201d funded by the Merck Investigator-Initiated Studies Program, awarded to Dr. Brown as Principal Investigator, 4\/1\/25-09\/30\/26.<\/p>\n

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\u201cScaling Access to LAMFit<\/a>: A Digital Fitness Program for LAM\u201d<\/strong> funded by The LAM Foundation, 2024 Clinical Investigator Award, to Dr. Claire Child as Principal Investigator, Dr. Brown as co-Investigator, 04\/1\/25 \u2013 03\/30\/27. <\/p>\n<\/p>\n

“Right Ventricular Response to Exercise Among Patients with Chronic Obstructive Pulmonary Disease”<\/strong> grant # is 1K23HL175186-01A1 (NHLBI), to Dr. Lindsay \u201cShelley\u201d Forbes, Indiana University,  Dr. Brown as co-mentor\/collaborator 8\/1\/25-5\/1\/30.<\/p>\n

\u201cTargeting metabolic syndrome from the emergency department through mixed-methods\u201d<\/strong> Funded by the Society for Academic Emergency Medicine Foundation, to Dr. Lauren Steward, Indiana University, Dr. Brown as co-mentor\/collaborator, 7\/2024 to 6\/2026  <\/p>\n

Completed recent projects<\/h2>\n
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Introducing “LAMFit”- An mHealth Program to Expand Access to the Health Benefits of Exercise\u00a0for\u00a0LAM<\/strong>
Read more about this exciting new project, the next step from the recently-completed “LAM Exercise & Fatigue Study”, here:
LAM Foundation Research Portfolio<\/a><\/p>\n

\u2018Mobile health to increase patient accessibility to exercise and elucidate exercise & fatigue in Lymphangioleiomyomatosis (LAM)\u2019<\/strong>, funded by a Patient Benefit Grant from The LAM Foundation to Dr. Brown as Principal Investigator, 12\/1\/18-11\/30\/21<\/p>\n

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\u2018A Mixed Methods Usability Study of a Mobile Health Exercise Platform for Adults with Idiopathic Pulmonary Fibrosis\u2019<\/strong>, funded by a grant from the American Physical Therapy Association (APTA) Academy of Cardiovascular and Pulmonary Physical for PhD student Claire Child in the Brown Lab, 1\/22-1\/23.<\/p>\n

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\u2018Maximizing Benefit and Minimizing Detriment of Exercise for Duchene Muscular Dystrophy\u2019<\/strong> funded by the Research Royalty Fund of University of Washington, with collaborator Dr. David Mack, 06\/1\/20 – 05\/31\/22 <\/p>\n

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\"Participants<\/figure>\n<\/div>\n

‘A Mobile Health Exercise Prescription to Enhance Effectiveness of Antifibrotic Therapy in Patients with IPF.<\/strong>‘
The study began enrollment in early 2021 and will investigate the following: whether prescribed exercise increases habitual physical activity and reduces sedentary behavior in patients with IPF on antifibrotic therapy; whether effectiveness of antifibrotics to slow decline in lung function, quality of life, and exercise tolerance in patients with IPF is enhanced with a concomitant mHealth home exercise program; Feasibility, adherence, and safety of an mHealth home exercise program for patients with IPF; and the usefulness of long-term physical activity behavior assessed via patient-worn sensors as an endpoint for IPF trials. <\/p>\n

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\"Mouse<\/figure>\n<\/div>\n

\u2018Maximizing Benefit and Minimizing Detriment of Exercise for Pulmonary Hypertension\u2019<\/strong> funded by the National Heart, Lung, and Blood Institute (NHLBI) of the NIH to Dr. Brown as PI (1 R15 HL121661-01A1).<\/p>\n

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\u2018Estrogen receptor-alpha effects on right ventricular vascular density and angiogenesis in pulmonary hypertension\u2019<\/strong>, funded by a VA BLRD Merit Award to Principal investigator Tim Lahm, MD, Indiana University School of Medicine, 10\/1\/17 \u2013 09\/30\/21<\/p>\n

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\u2018Optimizing Aerobic Exercise as Therapy in Rats with Pulmonary Arterial Hypertension\u2019<\/strong> funded by the American Heart Association, Midwest Affiliate, Scientist Development Grant to Dr. Brown as PI.<\/p>\n

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\"Images<\/figure>\n<\/div>\n

 \u2018Exercise to attenuate right ventricular damage after pulmonary embolism\u2019<\/strong> funded by the Indiana Clinical and Translational Science Institute- Collaborative Translational Research to Dr. Brown and Dr. Jeff Kline of Indiana University School of Medicine as co-PIs.  <\/p>\n

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\u2018Clinical investigation of a daily walking program plus L-Arginine supplementation for the treatment of pulmonary arterial hypertension\u2019 <\/strong>funded by the American Thoracic Society-Pulmonary Hypertension Association, Proof of Concept Grant to Dr. Brown as PI.<\/p>\n<\/p>\n

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Pending projects<\/h2>\n

Utility of an innovative mobile health platform to enhance feasibility and translatability of large-scale exercise intervention trials<\/p>\n

A Mobile Health Exercise Prescription to Improve Glycemic Control in Cystic Fibrosis-Related Diabetes<\/p>\n

Prescribing Safer Exercise Using Threshold of Right Ventricular-Pulmonary Artery Uncoupling<\/p>\n","protected":false},"excerpt":{"rendered":"

Ongoing projects “Remotely-monitored Exercise to Enhance Functional Outcomes in Patients with Pulmonary Arterial Hypertension (PAH) Initiating Sotatercept Therapy: A Single-site Feasibility Study\u201d funded by the Merck Investigator-Initiated Studies Program, awarded to Dr. Brown as Principal Investigator, 4\/1\/25-09\/30\/26. \u201cScaling Access to LAMFit: A Digital Fitness Program for LAM\u201d funded by The LAM Foundation, 2024 Clinical Investigator…<\/p>\n

Read more<\/a><\/div>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-84","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/uwdpt-research.rehab.washington.edu\/brown-cardiopulmonary\/wp-json\/wp\/v2\/pages\/84","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/uwdpt-research.rehab.washington.edu\/brown-cardiopulmonary\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/uwdpt-research.rehab.washington.edu\/brown-cardiopulmonary\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/uwdpt-research.rehab.washington.edu\/brown-cardiopulmonary\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/uwdpt-research.rehab.washington.edu\/brown-cardiopulmonary\/wp-json\/wp\/v2\/comments?post=84"}],"version-history":[{"count":28,"href":"https:\/\/uwdpt-research.rehab.washington.edu\/brown-cardiopulmonary\/wp-json\/wp\/v2\/pages\/84\/revisions"}],"predecessor-version":[{"id":246,"href":"https:\/\/uwdpt-research.rehab.washington.edu\/brown-cardiopulmonary\/wp-json\/wp\/v2\/pages\/84\/revisions\/246"}],"wp:attachment":[{"href":"https:\/\/uwdpt-research.rehab.washington.edu\/brown-cardiopulmonary\/wp-json\/wp\/v2\/media?parent=84"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}