Projects

Ongoing projects

Introducing “LAMFit”- An mHealth Program to Expand Access to the Health Benefits of Exercise for LAM
Read more about this exciting new project, the next step from the recently-completed “LAM Exercise & Fatigue Study”, here:

LAM Foundation Research Portfolio

‘Mobile health to increase patient accessibility to exercise and elucidate exercise & fatigue in Lymphangioleiomyomatosis (LAM)’, funded by a Patient Benefit Grant from The LAM Foundation to Dr. Brown as Principal Investigator, 12/1/18-11/30/21

‘A Mixed Methods Usability Study of a Mobile Health Exercise Platform for Adults with Idiopathic Pulmonary Fibrosis’, funded by a grant from the American Physical Therapy Association (APTA) Academy of Cardiovascular and Pulmonary Physical for PhD student Claire Child in the Brown Lab, 1/22-1/23.

‘Maximizing Benefit and Minimizing Detriment of Exercise for Duchene Muscular Dystrophy’ funded by the Research Royalty Fund of University of Washington, with collaborator Dr. David Mack, 06/1/20 – 05/31/22

Completed recent projects

‘A Mobile Health Exercise Prescription to Enhance Effectiveness of Antifibrotic Therapy in Patients with IPF.‘
The study began enrollment in early 2021 and will investigate the following: whether prescribed exercise increases habitual physical activity and reduces sedentary behavior in patients with IPF on antifibrotic therapy; whether effectiveness of antifibrotics to slow decline in lung function, quality of life, and exercise tolerance in patients with IPF is enhanced with a concomitant mHealth home exercise program; Feasibility, adherence, and safety of an mHealth home exercise program for patients with IPF; and the usefulness of long-term physical activity behavior assessed via patient-worn sensors as an endpoint for IPF trials. 

‘Maximizing Benefit and Minimizing Detriment of Exercise for Pulmonary Hypertension’ funded by the National Heart, Lung, and Blood Institute (NHLBI) of the NIH to Dr. Brown as PI (1 R15 HL121661-01A1).

‘Estrogen receptor-alpha effects on right ventricular vascular density and angiogenesis in pulmonary hypertension’, funded by a VA BLRD Merit Award to Principal investigator Tim Lahm, MD, Indiana University School of Medicine, 10/1/17 – 09/30/21

‘Optimizing Aerobic Exercise as Therapy in Rats with Pulmonary Arterial Hypertension’ funded by the American Heart Association, Midwest Affiliate, Scientist Development Grant to Dr. Brown as PI.

 ‘Exercise to attenuate right ventricular damage after pulmonary embolism’ funded by the Indiana Clinical and Translational Science Institute- Collaborative Translational Research to Dr. Brown and Dr. Jeff Kline of Indiana University School of Medicine as co-PIs.  

‘Clinical investigation of a daily walking program plus L-Arginine supplementation for the treatment of pulmonary arterial hypertension’ funded by the American Thoracic Society-Pulmonary Hypertension Association, Proof of Concept Grant to Dr. Brown as PI.

Pending projects

Utility of an innovative mobile health platform to enhance feasibility and translatability of large-scale exercise intervention trials

A Mobile Health Exercise Prescription to Improve Glycemic Control in Cystic Fibrosis-Related Diabetes

Prescribing Safer Exercise Using Threshold of Right Ventricular-Pulmonary Artery Uncoupling